Technical services
General Toxicology
General Toxicology
We have an experienced team of toxicology specialists and a team of highly qualified experts—both domestic and international—who can provide clients with scientifically sound study designs and dose selections to ensure the smooth conduct of toxicology studies. Our general toxicology studies comply with international GLP regulatory standards, and our study designs meet the requirements of relevant guidelines issued by the NMPA (CFDA), U.S. FDA, OECD, and ICH, enabling us to satisfy the requirements for clinical trial applications or market approvals in various countries and regions.
Type of experiment
• Dose-ranging study
• Single-dose toxicity test
• Repeated-dose toxicity study with toxicokinetics (1/3/6/9 months)
• Allergy test:
- Active systemic allergy test, passive skin allergy test, active skin allergy test, and photoallergy test
- Guinea pig maximization test, closed patch test, and mouse local lymph node assay
• Hemolytic assays: in vitro hemolysis assays and in vivo hemolysis assays in animals
• Local irritation tests: vascular, skin, mucosal, and muscle irritation tests
• In vivo phototoxicity test
• In vitro phototoxicity assay (3T3 cells)
• T-cell-dependent antibody response assay
Test animal species
Mouse, rat, guinea pig, rabbit, dog, non-human primates (crab-eating macaque, rhesus monkey), miniature pig, golden hamster, immunodeficient mice
Route of administration
Oral (gavage, capsules), nasogastric feeding, topical application to skin and mucous membranes, intravenous (bolus injection, continuous infusion)
Subcutaneous, intradermal, and intramuscular injections
Intravenous, intra-articular, vaginal, rectal, intracranial, and intratumoral injections
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