Safety pharmacology

The purpose of safety pharmacology studies is to identify unexpected pharmacological effects that may be relevant to clinical safety, evaluate adverse pharmacological or pathophysiological responses observed in toxicology studies or clinical trials, and explore the underlying mechanisms responsible for these adverse reactions. We have an experienced team of safety pharmacology specialists and advanced, fully equipped imported experimental facilities, enabling us to provide clients with a comprehensive suite of safety pharmacology testing services that comply with CFDA, ICH S7A and S7B guidelines, as well as international GLP standards.

Safety pharmacology

The purpose of safety pharmacology studies is to identify unexpected pharmacological effects that may be relevant to clinical safety, evaluate adverse pharmacological or pathophysiological responses observed in toxicology studies or clinical trials, and explore the underlying mechanisms responsible for these adverse reactions. We have an experienced team of safety pharmacology specialists and state-of-the-art, fully equipped imported experimental facilities, enabling us to provide clients with a comprehensive suite of safety pharmacology testing services that comply with CFDA, ICH S7A and S7B guidelines, as well as international GLP standards.

 

 

Instrumental equipment

 

Multi-channel physiological data acquisition system

DSI Physiological Data Acquisition and Analysis System (Telemetry System)

Spontaneous Activity Video Capture and Analysis System

Whole-body volumetric imaging system

Vest telemetry system

 

 

Animal species

 

Dog/non-human primates

Mouse/Rat

 

 

Core portfolio

 

Cardiovascular System: Awake dogs and monkeys (telemetry: ECG / blood pressure / heart rate / body temperature); anesthetized dogs and monkeys (ECG / blood pressure / heart rate / respiration).

Respiratory System (Rat/Mouse): Respiratory Rate/Tidal Volume/Minute Ventilation, Central Nervous System (Rat/Mouse/Monkey), Functional Observation Battery, Modified Irwin Method

In vitro electrophysiology: potassium ion channels (hERG), sodium ion channels, and calcium ion channels

 

 

Additional testing

 

Central Nervous System: Behavior, Learning, and Memory, etc.

Cardiovascular System: Myocardial Contractility, Action Potentials

Respiratory system: airway resistance, etc.

 

 

Supplementary experiment

 

Gastrointestinal system

Urogenital/Kidney System

Neuromuscular function

Neuromuscular coordination