Toxicokinetics

Small-molecule bioanalysis is a branch of analytical chemistry that focuses on the quantitative determination of small-molecule compounds as well as certain macromolecules (such as proteins, DNA, metabolites, and large-molecule drugs). In recent years, biotechnology-based drugs have become a major research and development focus, and bioanalysis has gradually attracted increasing attention from companies due to its critical role in the early stages of biotech drug development. We have a highly specialized research team, an analytical laboratory equipped with state-of-the-art instruments and devices, and a fully integrated information management system. Our experimental studies comply with GLP standards, and we develop, transfer, and optimize LC-MS/MS methods for the quantification of drug concentrations in biological matrices. Our services encompass the development, validation, and transfer of bioanalytical methods, as well as bioanalytical method verification; toxicokinetic and pharmacokinetic sample analysis—including plasma, serum, tumor tissues, heart, liver, spleen, lung, kidney, duodenum, body fat, skeletal muscle, testes, and ovaries—and the calculation of toxicokinetic and pharmacokinetic parameters. We provide non-clinical research services for small-molecule drugs, biologics, and other similar substances to our clients.

Toxicokinetics

Small-molecule bioanalysis

 

Small-molecule bioanalysis is a branch of analytical chemistry that focuses on the quantitative determination of small-molecule compounds as well as certain macromolecules (such as proteins, DNA, metabolites, and large-molecular-weight drugs). In recent years, biotechnology-derived drugs have become a major research and development focus, and bioanalysis has gradually attracted greater attention from companies due to its critical role in the early stages of biotech drug development. We have a highly specialized research team, an analytical laboratory equipped with state-of-the-art instrumentation, and a fully integrated information management system. Our experimental studies comply with GLP standards, and we develop, transfer, and optimize LC-MS/MS methods for the quantification of drug concentrations in biological matrices. Our services encompass the development, validation, and transfer of bioanalytical methods, as well as bioanalytical method verification; toxicokinetic and pharmacokinetic sample analysis—including plasma, serum, tumor tissues, heart, liver, spleen, lung, kidney, duodenum, body fat, skeletal muscle, testes, and ovaries—and the calculation of toxicokinetic and pharmacokinetic parameters. We provide non-clinical research services for small-molecule drugs, biologics, and other similar substances to our clients.

 

Type of experiment

 

Bioanalytical Method Development, Validation, and Transfer

Validation of Bioanalytical Methodology

Non-clinical Toxicokinetic Sample Analysis

Non-clinical Pharmacokinetic Sample Analysis