Technical services
Metabolic Stability: Hepatocytes / Liver S9 / Liver Microsomes Metabolite Identification Assay (Metabolic Species Differences) Metabolite analysis following 3H/14C labeling of compounds
Tissue distribution determination Brain/Blood Ratio Study of the Test Substance Whole blood plasma distribution ratio Plasma Protein Binding: Equilibrium Dialysis Method/Ultrafiltration Membrane Method After administration of 125I-labeled macromolecular drugs, measure the total radioactivity and the precipitated radioactivity in tissues. Determination of radioactivity in tissues after administration of 3H/14C-labeled small-molecule drugs.
Absorption Assessment of Single-Dose or Repeated-Dose Administration Absorption Assessment of Drug Administration via Non-Rodent Double-Crossover and Latin Square Designs Pharmacokinetic-Pharmacodynamic Studies of Biological Products
Pharmacological Evaluation of Metabolic System Diseases (Obesity/Diabetes and Complications, Hyperglycemic Clamp Study, Insulin Resistance, Hyperuricemia, Obesity, etc.) Inflammatory and Immune System Diseases Efficacy evaluation of drug candidates in pediatric disease models (chronic visceral hypersensitivity model in young rats, precocious puberty, etc.) and respiratory disease models (pulmonary fibrosis). Urinary System Diseases (Drug- and Surgery-Induced Renal Injury, Renal Insufficiency) Liver diseases (such as hepatic ascites, liver cirrhosis, liver fibrosis, alcoholic liver disease, etc.), skin and ophthalmological disorders, and others.
Cardiovascular and cerebrovascular disease drug efficacy
Central/Peripheral Nervous System (Cerebral Ischemia, AD, Depression/Anxiety, Drug Dependence, etc.) Cardiovascular system (myocardial ischemia, hyperlipidemia and atherosclerosis, heart failure, arrhythmias, hypertension, etc.)
Imaging Platform (PET/MR) Imaging Evaluation of Tumor-Targeted Drugs / Pharmacodynamic Evaluation of Antitumor Drugs Pharmacodynamic Evaluation of Cardiovascular and Cerebrovascular Diseases (including Cerebral Ischemia, Myocardial Ischemia, AD, etc.)
Subcutaneous Tumor Xenografts: Cell-Derived Xenograft (CDX) Models, Patient-Derived Xenograft (PDX) Models of Human Tumors In situ tumor transplantation models (e.g., brain, lung, liver, ascitic tumors) equipped with in vivo imaging detection capabilities. Tumor immunotherapy mouse models: immune-reconstituted mouse tumor models, syngeneic transplant mouse models, genetically engineered humanized models (GEMMs), and in vitro assays (cell uptake; cytotoxicity, apoptosis, necrosis; cell invasion, metastasis, etc.).
SPF-grade animal facilities house mice, rats, guinea pigs, and rabbits; general-grade animal facilities house guinea pigs, rabbits, dogs, monkeys, and pigs.