Distribution study

Tissue distribution determination Brain/Blood Ratio Study of the Test Substance Whole blood plasma distribution ratio Plasma Protein Binding: Equilibrium Dialysis Method/Ultrafiltration Membrane Method After administration of 125I-labeled macromolecular drugs, measure the total radioactivity and the precipitated radioactivity in tissues. Determination of radioactivity in tissues after administration of 3H/14C-labeled small-molecule drugs.

Distribution study

Tissue distribution determination

Brain/Blood Ratio Study of the Test Substance

Whole blood plasma distribution ratio

Plasma protein binding: Balanced Dialysis Method/Ultrafiltration Membrane Method

After administration of 125I-labeled macromolecular drugs, measure the total radioactivity and the precipitated radioactivity in tissues.

Determine radioactivity in tissues after administration of 3H/14C-labeled small-molecule drugs.