Phototoxicity Assessment

Light is beneficial to health, and many medications themselves do not harm the human body. However, under the influence of light, certain drugs can induce phototoxicity. In such cases, it becomes necessary to conduct a phototoxicity assessment. We have established both in vivo and in vitro phototoxicity evaluation methods in accordance with the requirements of ICH S10 and NMPA, and we have over ten years of experience in dermatological phototoxicity assessments.

Phototoxicity Assessment

Light is beneficial to health, and many medications themselves do not harm the human body. However, under the influence of light, certain drugs can induce phototoxicity. In such cases, it is necessary to consider conducting a phototoxicity assessment. We have established both in vivo and in vitro phototoxicity evaluation methods in accordance with the requirements of ICH S10 and NMPA, and we have over ten years of experience in skin phototoxicity assessment.

 

Phototoxicity Test

 

In vitro phototoxicity assay:

 

Neutral Red Phototoxicity Assay in 3T3 Cells

 

In vivo phototoxicity test (guinea pig, rat, mouse):

 

Neutral Red Phototoxicity Assay in 3T3 Cells In Vitro

Skin Phototoxicity Study in Guinea Pigs: Intravenous and Topical Administration

Skin Phototoxicity Study in Rats: Oral and Topical Administration

Skin Phototoxicity Study in Mice: Intravenous and Topical Administration

Skin Phototoxicity Study in BN Rats: Intravenous and Topical Administration

Guinea Pig Skin Phototoxicity Test

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