Technical services
Ophthalmic Toxicology
Ophthalmic Toxicology
I. Introduction
We conduct safety and efficacy evaluations of ophthalmic drugs, as well as studies on the effects of systemic drug administration on the eyes. We are proficient in various intraocular drug delivery methods across different animal species and have established experimental animal models for conditions such as corneal neovascularization, corneal epithelial damage, and cataracts. Equipped with advanced ophthalmic diagnostic instruments—including slit lamps, tonometers, fundus cameras, OCT systems, electroretinographs, and surgical microscopes—we are able to perform comprehensive in vivo ophthalmic examinations, thereby providing crucial support for preclinical research on ophthalmic drugs.
II. Main Research Contents
1. Non-clinical studies of ophthalmic drugs:
Safety evaluation, efficacy evaluation, pharmacokinetics/toxicokinetics (ocular circulation)
2. Animal species:
Rodents (large and small mice), rabbits, dogs, non-human primates
3. Route of administration:
Topical ocular administration: Administered into the conjunctival sac.
Intraocular injections: anterior chamber injection, vitreous cavity injection, subconjunctival injection, retrobulbar injection
Systemic administration: intravenous injection, oral administration, intramuscular injection, subcutaneous injection
4. Ophthalmic disease models:
| Clinical disease | Modeling method | Animal species |
| Corneal neovascularization | Corneal Suture Induction | New Zealand White Rabbit |
| Alkali burn-induced | ||
| Corneal epithelial injury | Corneal epithelial cell scraping-induced | New Zealand White Rabbit |
| Cataract | Sodium selenite subcutaneous injection-induced | SD rat |
| Retinal melanin deposition | Rituximab-induced | Long Evans rat |
5. In vivo ophthalmic examination:
Slit-lamp examination, corneal fluorescein sodium staining examination
Direct/Indirect Ophthalmoscopy Examination
Fundus Photography FP
Fundus Fluorescein Angiography FFA
Optical Coherence Tomography OCT
Infrared Reflectance Imaging IR
Fundus Autofluorescence Scanning BAF
Intraocular pressure IOP
Electroretinogram ERG
Visual Evoked Potential (VEP)
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Contact phone number
Ms. Li:+86 15760970681
Mr. Su:+86 19991001701
Landline:+86-29-33656828
Company Address
4th Floor, Unit C. Building 9. Small and Medium-sized
Enterprise Park, Airport Industrial Zone Airport New Ciy,Xixian New Area, Shaanxi Province
©2026 Xixian New Area Guorui Yinuo Drug Safety Evaluation and Research Co., Ltd.
WhatsApp：8613940397353
Email：hr-xian@grglp.com
Landline：862933656828
Mr. Su：8619991001701
Ms. Li：8615760970681