Technical services
Genetic toxicology
Genetic toxicology
Genotoxicity studies can predict the genotoxic effects of drugs and chemicals, including mutagenicity, clastogenicity, and DNA damage. We offer all assays included in the ICH S2(R1) standard battery and comply with international GLP regulatory guidelines. Our assay protocols are designed to meet the requirements of guidance documents issued by the U.S. FDA, U.S. EPA, ICH, OECD, and CFDA. Years of accumulated extensive historical control databases, a stable technical team, and highly qualified senior researchers ensure that we can provide our clients with high-quality services promptly and effectively. We are committed to developing cutting-edge genotoxicity methodologies and applying automated systems such as flow cytometry to genotoxicity research. We have participated multiple times in collaborative validation studies of new genotoxicity technologies and methods both domestically and internationally. In addition to the ICH standard assay battery, we can also provide clients with studies on genotoxicity mechanisms and additional assay methods, as well as genotoxicity assessments of impurities that meet the requirements of ICH M7.
Experimental system
Cells: CHL, CHO, TK6, L5178Y, 3T3, etc. (purchased from ATCC)
S9 (purchased from MOLTOX)
Strain (purchased from MOLTOX):
—Salmonella typhimurium: TA97a, TA98, TA100, TA102, TA1535, TA1537
—Escherichia coli: E. Coli WP2 uvrA and E. Coli WP2 uvrA (pKM101)
Core Combination Test
Ames Test (OECD 471)
In Vitro and In Vivo Chromosome Aberration Tests (OECD 473/475)
Gene Mutation Assay (MLA, HGPRT, or XGPRT) (OECD 490/476)
In vitro and in vivo micronucleus assays (Manual & FCM) (OECD 487/474)
Comet Assay IV Software for In Vivo Multi-Organ Comet Assay (OECD 489)
Additional Trials/Mechanism Studies
In Vitro and In Vivo Pig-a Gene Mutation Assays
Multi-endpoint genotoxicity assay (γ-H2AX, p53, H3, Cleaved-PARP)
In vivo liver micronucleus assay
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Contact phone number
Ms. Li:+86 15760970681
Mr. Su:+86 19991001701
Landline:+86-29-33656828
Company Address
4th Floor, Unit C. Building 9. Small and Medium-sized
Enterprise Park, Airport Industrial Zone Airport New Ciy,Xixian New Area, Shaanxi Province
©2026 Xixian New Area Guorui Yinuo Drug Safety Evaluation and Research Co., Ltd.
WhatsApp：8613940397353
Email：hr-xian@grglp.com
Landline：862933656828
Mr. Su：8619991001701
Ms. Li：8615760970681