Excretion Study

Metabolic cage collection of urine and feces for LC-MS/MS analysis Rat bile duct cannulation and bile collection for LC-MS/MS analysis. After radiolabeling with 3H/14C isotopes, the radioactivity in feces, urine, and bile is measured (online radioactivity monitoring—HPLC-mass spectrometry). 125I-labeled drug, determination of total radioactivity in feces, urine, and bile

Excretion Study

Metabolic cage collection of urine and feces for LC-MS/MS analysis

Rat bile duct cannulation and bile collection for LC-MS/MS analysis.

After radiolabeling with 3H/14C isotopes, the radioactivity in feces, urine, and bile is measured (online radioactivity monitoring—HPLC-mass spectrometry).

125I-labeled drug, determination of total radioactivity in feces, urine, and bile