Drug Interaction Studies

Inhibition assays: 1) Reversible inhibition 2) Time-dependent inhibition Metabolic Phenotype Assays: 1) CYP—chemical inhibition and recombinant enzyme methods; 2) UGT—recombinant enzyme method. Enzyme induction: CYP450 enzyme subtypes (1A2, 2B6, and 3A4) Transporter Assay: ABC transporter substrate assays (P-gp and BCRP); vesicle systems or Caco-2 cells; ABC Transporter Substrate Inhibition Assay (P-gp and BCRP): Vesicle System; SLC Transporter Substrate Assays (OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1, MATE2K) SLC Transporter Inhibition Assays (OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1, MATE2K)

Inhibition experiment: 1) Reversible inhibition 2) Time-dependent inhibition

Metabolic Phenotype Assay: 1) CYP: Chemical Inhibition Method and Recombinant Enzyme Method; 2) UGT: Recombinant Enzyme Method

Enzyme induction: CYP450 enzyme subtypes (1A2, 2B6, and 3A4)

Transporter Assay:

ABC transporter substrate assays (P-gp and BCRP); vesicle systems or Caco-2 cells;

ABC Transporter Substrate Inhibition Assay (P-gp and BCRP): Vesicle System;

SLC Transporter Substrate Assays (OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1, MATE2K)

SLC Transporter Inhibition Assays (OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1, MATE2K)

In vivo pharmacokinetic studies

Excretion Study

In vivo pharmacokinetic studies

Excretion Study

Contact phone number

Ms. Li:+86 15760970681
Mr. Su:+86 19991001701
Landline:+86-29-33656828

hr-xian@grglp.com

Company Address

4th Floor, Unit C. Building 9. Small and Medium-sized

Enterprise Park, Airport Industrial Zone Airport New Ciy,Xixian New Area, Shaanxi Province

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WhatsApp：8613940397353

Email：hr-xian@grglp.com

Landline：862933656828

Mr. Su：8619991001701

Ms. Li：8615760970681

Drug Interaction Studies

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