Toxicological Evaluation of Pesticide Registration Trials

Pesticides are chemical agents used in agriculture to control pests and diseases, as well as to regulate plant growth. They are widely applied in agricultural, forestry, and animal husbandry production, environmental and household pest control and disease prevention, and the prevention of mold and insect damage in industrial products. There are many types of pesticides; classified by use, they can be mainly divided into insecticides, acaricides, rodenticides, nematicides, molluscicides, fungicides, herbicides, and plant growth regulators. Classified by their source materials, they can be divided into mineral-origin pesticides (inorganic pesticides), bio-origin pesticides (natural organic substances, microorganisms, antibiotics, etc.), and chemically synthesized pesticides. By chemical structure, they mainly include organochlorines, organophosphates, organonitrogens, organosulfurs, carbamates, pyrethroids, amide compounds, urea compounds, ether compounds, phenol compounds, phenoxy carboxylic acids, amidines, triazoles, heterocyclic compounds, benzoic acid compounds, and organometallic compounds—all of which are synthetically produced pesticides. According to their formulation type, they can be categorized into powders, wettable powders, emulsions, emulsifiable concentrates, creams, pastes, colloidal formulations, fumigants, fumigating agents, smoke agents, granules, microgranules, and oil formulations, among others.

Toxicological Evaluation of Pesticide Registration Trials

 
 
Serial number
Testing items
Acute toxicity
Experiment
1
Acute Oral Toxicity Study in Rats
2
Acute Dermal Toxicity Test in Rats
3
Acute Eye Irritation/Corrosion Test in Rabbits
4
Acute Skin Irritation/Corrosion Test in Rabbits
5
Guinea Pig Skin Sensitization Test
6
Acute Inhalation Toxicity Study in Rats
Repeated exposure
Toxicity test
7
28-Day Repeated Dermal Toxicity Study in Rats
8
28-Day Inhalation Toxicity Study in Rats Following Repeated Exposure
9
Subchronic (90-day) Oral Toxicity Study in Rats
Special toxicity
Experiment
10
Reproductive Toxicity Study in Rabbits During Pregnancy
11
Rat Prenatal Developmental Toxicity Study
12
Two-Generation Reproductive Toxicity Study in Rats
13
Mouse bone marrow erythrocyte micronucleus assay
14
In Vitro Mammalian Cell Gene Mutation Assay
15
In vitro mammalian cell chromosome aberration assay
16
Bacterial Reverse Mutation Assay
17
Analytical Method Validation
18
Mouse carcinogenicity test
19
Chronic and Carcinogenic Combined Studies in Mice
20
Mouse Neurotoxicity Test
21
Acute Delayed Neurotoxicity Test in Chickens
Metabolic toxin
Kinetic test
22
Toxicokinetic study

 

Test Scope
Acute Toxicity Test
Repetitive Dose Toxicity Study
Metabolic Toxicokinetics Study
Poison
reason
study
Try
Test
Acute Oral Toxicity Test
Acute Dermal Toxicity Test
Acute Inhalation Toxicity Test
Eye irritation test
Skin Irritation Test
Skin Sensitization Test
Subchronic (or Acute) Oral Toxicity Study
Subchronic (Acute) Dermal Toxicity Test
Subchronic (or Acute) Inhalation Toxicity Study
Chronic toxicity test
 
 

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